PGD is generally used by couples with a family history of a serious or deadly disease who worry about passing it on to their offspring. PGD helps by looking for specific markers for a certain disease, for example, single gene disorders including cystic fibrosis and sickle cell anemia. It is also used when there’s a family history of sex-linked disorders including Fragile X syndrome and Duchenne muscular dystrophy. Parents may also use PGD to find matching stem cells for other siblings in need of a bone marrow transplant.
- Women aged more than 35 years;
- Couples, whose anamnesis contains repeated natural abortions before 12 weeks;
- Couples having multiple failed cycles of infertility treatment by means of IVF;
- Couples, whose karyotype has chromosomal disorders.